Key result
The mouse cardiac troponin I gene contains 8 exons and its 5'-flanking sequence includes a minimal promoter and two upstream cardiac-specific positive regions separated by a negative region.
Population
Mouse cardiac troponin I gene and cultured cardiac and skeletal muscle cells
Design
Preclinical
Authors
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No immediate clinical application; leaves open whether these murine regulatory elements inform human troponin I-targeted therapies.
The study characterizes the structure of the mouse cardiac troponin I gene and identifies specific regulatory regions in its 5'-flanking sequence that control its cardiac-specific expression.
Ausoni et al. (1994) studied this question. The mouse cardiac troponin I gene contains 8 exons and its 5'-flanking sequence includes a minimal promoter and two upstream cardiac-specific positive regions separated by a negative region.
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