What is the clinical evidence from this study?

Study design: Review. Population: Volume expanded hypertension. Intervention: Volume expansion.

What question did this study set out to answer?

Investigate whether altered sodium-potassium pump activity contributes to the pathogenesis of volume-expanded hypertension.

January 1, 1978Clinical and experimental hypertension

The Sodium-Potassium Pump in Volume Expanded Hypertension

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Key result

Volume expansion, reduced Na+-K+ pump activity, and hypertension appear causally related through an ouabain-like humoral agent that increases contractile activity in arteries, veins, and heart.

Population

Experimental models of volume expanded hypertension (including rats)

Design

Review

Authors

FHFrancis J. HaddyUniversity of Vermont MPMotalil PamnaniUniformed Services University of the Health Sciences DCDavid CloughUniversity of Aberdeen

Discussion

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Implication

Hypothesis-generating for ouabain-like factor in volume-expanded hypertension; prospective trials required before clinical consideration.

Key Points

Investigate whether altered sodium-potassium pump activity contributes to the pathogenesis of volume-expanded hypertension.
Measured arterial and cardiac Na+-K+ pump and Na+, K+-ATPase activity across low-pressure and high-pressure cardiovascular tissues in experimental hypertension.
Subjected normal rats to acute volume expansion and treated donor arteries with plasma extracts from expanded animals.
Assessed vascular and cardiac contractile responses following pump inhibition with ouabain.
Arterial and cardiac Na+-K+ pump activity decreased across both high-pressure arteries and low-pressure veins and right ventricles, demonstrating that suppression is not secondary to high blood pressure.
Plasma extracts from acutely volume-expanded rats directly suppressed Na+-K+ pump activity when applied to normal arterial tissue.
Pharmacological pump suppression induced heightened contractile activity in vascular and cardiac tissue and extended defects to sympathetic nerve endings.

Structured PICO

Population

Experimental models of volume expanded hypertension (including rats)

Outcome

Arterial Na+-K+ pump and cardiac Na+, K+-ATPase activitiessurrogate

Volume expanded hypertension may be causally related to reduced Na+-K+ pump activity mediated by an ouabain-like humoral agent.

Cite This Study

Haddy et al. (1978) conducted a review in Volume expanded hypertension. Volume expansion was evaluated. Volume expansion, reduced Na+-K+ pump activity, and hypertension appear causally related through an ouabain-like humoral agent that increases contractile activity in arteries, veins, and heart.

synapsesocial.com/papers/6a0d537dcae7912d2fa4e878 https://doi.org/10.3109/10641967809068611

Topics

Hypertension management

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The Sodium-Potassium Pump in Volume Expanded Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

The Sodium-Potassium Pump in Volume Expanded Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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