Key result
The initial action potential spike triggers phasic contractions in guinea-pig ureter smooth muscle, whereas the plateau determines contraction amplitude and duration.
Population
Smooth muscle cells of guinea-pig ureter
Comparison
Na-free and K-free solutions, tetraethyl… vs Baseline/normal conditions
Design
Preclinical
Authors
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Informs excitation-contraction coupling in ureter smooth muscle; hypothesis-generating for human translation.
In guinea-pig ureter smooth muscle, phasic contractions are triggered by the initial spike of the action potential, while the plateau phase determines contraction amplitude and duration.
M. F. Shuba (1977) studied this question. The initial action potential spike triggers phasic contractions in guinea-pig ureter smooth muscle, whereas the plateau determines contraction amplitude and duration.
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