Key result
Aortic calcification was positively associated with aortic pulse wave velocity (r=0.6; P<0.0001) and was significantly higher in subjects with isolated systolic hypertension than in controls.
Why the study?
Is aortic calcification associated with aortic stiffness and isolated systolic hypertension?
Population
208 individuals, comprising 193 healthy, medication-free subjects from the community and 15 patients with…
Design
Cross-sectional
Authors
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Supports link between aortic calcification, stiffness, and isolated systolic hypertension; hypothesis-generating, should not yet change practice.
Cross-Sectional (n=208)
Is aortic calcification associated with aortic stiffness and isolated systolic hypertension?
Effect estimate: r=0.6
Absolute Event Rate: 1.92% vs 0.19%
p-value: p=<0.0001
Aortic calcification is independently associated with aortic stiffness and isolated systolic hypertension, suggesting it may play a role in arterial stiffening and treatment resistance.
McEniery et al. (2009) conducted a cross-sectional in Isolated systolic hypertension (n=208). Aortic calcification (exposure) vs. Healthy controls was evaluated on Aortic pulse wave velocity and aortic calcium content (r=0.6, p=<0.0001). Aortic calcification was positively associated with aortic pulse wave velocity (r=0.6; P<0.0001) and was significantly higher in subjects with isolated systolic hypertension than in controls.
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