Key result
In untreated patients with essential hypertension, the presence of left ventricular hypertrophy was associated with a significantly higher incidence of proteinuria (20% vs 8%) and advanced retinal vascular change.
Why the study?
Is left ventricular hypertrophy associated with increased renal and retinal damage in untreated patients with essential hypertension?
Cross-Sectional (n=174)
Single-blind
No
Is left ventricular hypertrophy associated with increased renal and retinal damage in untreated patients with essential hypertension?
In untreated essential hypertension, left ventricular hypertrophy is significantly associated with other markers of target organ damage, specifically proteinuria and retinal vascular changes.
Answers are grounded in this paper and cite their sources.
LVH may mark broader target organ damage in untreated hypertension; leaves open prognostic value and need for prospective validation.
We examined the relationship between left ventricular hypertrophy (LVH) and renal and retinal damage in 174 untreated patients with essential hypertension. As an index of renal and retinal damage, we examined proteinuria and retinal vascular change. LVH was diagnosed according to left ventricular mass obtained from echocardiography. Of the hypertensive patients, 111 patients (64%) had LVH. The incidences of proteinuria and advanced retinal vascular change were higher in patients with LVH than in those without LVH. In a multiple regression model, there was a significant positive correlation between left ventricular mass and proteinuria, as well as diastolic blood pressure, sex, age and body mass index. In conclusion, proteinuria is related to elevated left ventricular mass in patients with essential hypertension.
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Saitoh et al. (1998) conducted a cross-sectional in Essential hypertension (n=174). Left ventricular hypertrophy (LVH) vs. No LVH was evaluated on Incidence of proteinuria (p=<0.05). In untreated patients with essential hypertension, the presence of left ventricular hypertrophy was associated with a significantly higher incidence of proteinuria (20% vs 8%) and advanced retinal vascular change.
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