Key result
In patients with hypertension, the severity of hypertensive retinopathy was not significantly associated with the presence of left ventricular hypertrophy or proteinuria.
Why the study?
Hypertensive retinopathy is associated with other target organ damage, but its relationship with left ventricular hypertrophy and proteinuria was inconclusive in previous studies.
Is hypertensive retinopathy associated with left ventricular hypertrophy and proteinuria in hypertensive patients?
Cross-Sectional (n=100)
No
Is hypertensive retinopathy associated with left ventricular hypertrophy and proteinuria in hypertensive patients?
While severity of hypertension correlates with left ventricular hypertrophy and proteinuria, the grade of hypertensive retinopathy does not significantly associate with these target organ damages.
Answers are grounded in this paper and cite their sources.
Retinopathy severity may not indicate concurrent LVH or proteinuria; leaves open whether fundoscopy improves risk stratification beyond BP measurement.
Background: Hypertensive retinopathy is almost always associated with other target organ damage. Relationship of hypertensive retinopathy with left ventricular hypertrophy (LVH) and proteinuria was inconclusive in previous studies.Objective: To assess the relation between Left Ventricular Hypertrophy and Proteinuria in Hypertensive Patient with Retinopathy in Tertiary Care Hospital.Methods: This is a cross-sectional observational study and conducted at the Department of Medicine and Cardiology in Dhaka Medical College Hospital. Total 100 hypertensive retinopathy patients were included in the study. Following informed written consent, physical examination, relevant investigations were done. In all cases, Ethical issues were maintained properly and collected data were analysed by SPSS 20.Results: Among 100 participants, mean age was 57.15 (±12.989 SD) years [age range 29-85] and 61% were male & 39% were female. Mean value of Systolic (SBP) and Diastolic Blood pressure (DBP) in Grade (G)-1, G-2 and G-3 hypertension were 150.8 (± 5.4) & 94 (± 2.6) mm Hg, 170.3 ± 4.9 & 101.0 ± 4.7 mm Hg and 188.0 ± 7.0 & 102.6 ± 6.5 mm Hg respectively and it is significantly associated with severity of LVH (p value < 0.001 in both SBP & DBP). Proteinuria is also associated with severity of hypertension (p <0.001) but there were no association of Hypertensive retinopathy with LVH and proteinuria (p value 0.32 and 0.27 respectively).Conclusion: LVH & Proteinuria is associated with severity of Hypertension but Hypertensive retinopathy is not associated with LVH and proteinuria, though further large cohort is recommended for final comment.
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Saad Ahmed Tanmoy (2025) conducted a cross-sectional in Hypertension with retinopathy (n=100). Hypertensive retinopathy severity vs. Grade 1 hypertensive retinopathy was evaluated on Left ventricular hypertrophy (Grade 4 vs Grade 1 retinopathy) (OR 4.5, 95% CI 0.442-45.853, p=0.32). In patients with hypertension, the severity of hypertensive retinopathy was not significantly associated with the presence of left ventricular hypertrophy or proteinuria.
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