Key result
In female rats, the exercise pressor reflex and its mechanical component are significantly attenuated during the proestrus phase compared to the diestrus phase, likely mediated by estrogen.
Population
Female rats (decerebrate and ovariectomized models)
Comparison
Proestrus phase of the estrous cycle… vs Diestrus phase of the estrous cycle
Design
Preclinical
Authors
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Animal findings warrant no change in clinical exercise guidance; leaves open estrogen modulation of pressor reflex across human menstrual phases.
The exercise pressor reflex function fluctuates with the estrous cycle in female rats, likely due to the attenuating effects of estrogen on the spinal component of the reflex arc.
Koba et al. (2012) studied Exercise pressor reflex. Proestrus phase / 17β-estradiol vs. Diestrus phase was evaluated on Renal sympathoexcitatory and pressor responses to skeletal muscle contraction or passive stretch. In female rats, the exercise pressor reflex and its mechanical component are significantly attenuated during the proestrus phase compared to the diestrus phase, likely mediated by estrogen.
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