Key result
Treatment of ovariectomized rats with 17 beta-estradiol significantly enhanced baroreflex sensitivity (-1.41 vs -0.93 beats.min-1.mmHg-1; p < 0.05).
Why the study?
Does 17 beta-estradiol enhance baroreflex control of heart rate in ovariectomized rats?
Population
Conscious freely moving male and female Sprague-Dawley rats, and ovariectomized rats
Comparison
17 beta-estradiol for 2 days vs Vehicle treatment in ovariectomized rats…
Design
Preclinical
Follow-up
2 days
Authors
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Hypothesis-generating for estrogen's role in autonomic regulation; leaves open translation to human cardiovascular disease.
Does 17 beta-estradiol enhance baroreflex control of heart rate in ovariectomized rats?
Absolute Event Rate: -1.41% vs -0.93%
p-value: p=< 0.05
Estrogen treatment enhances baroreflex sensitivity in ovariectomized rats, suggesting a facilitatory role for estrogen in modulating baroreflex function.
El‐Mas et al. (1998) studied Baroreflex control of heart rate. 17 beta-estradiol vs. Vehicle was evaluated on Baroreflex sensitivity (beats.min-1.mmHg-1) (p=< 0.05). Treatment of ovariectomized rats with 17 beta-estradiol significantly enhanced baroreflex sensitivity (-1.41 vs -0.93 beats.min-1.mmHg-1; p < 0.05).
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