Why the study?
Does intravenous estrogen enhance baroreflex sensitivity in male rats?
Population
Male Sprague-Dawley rats anesthetized with thiobutabarbitol sodium (50 mg/kg)
Comparison
Intravenous injection of estrogen (17β-estradiol) vs Baseline conditions and vagal stimulation…
Design
Preclinical
Authors
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No direct clinical application from rat data; leaves open estrogen modulation of baroreflex sensitivity in humans.
Does intravenous estrogen enhance baroreflex sensitivity in male rats?
Intravenous estrogen acutely enhances baroreflex sensitivity in male rats and prevents its attenuation following vagal stimulation.
Saleh et al. (1998) studied this question.
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