Key result
Estrogen treatment significantly increased baroreflex sensitivity in ovariectomized rats (P<0.01), but blockade of β-adrenergic receptors in the NTS with propranolol did not alter this effect.
Estrogen increases baroreflex sensitivity in ovariectomized rats, but this effect is not mediated by beta-adrenergic receptors in the nucleus tractus solitarius.
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Estrogen enhances baroreflex sensitivity independently of NTS beta-adrenergic receptors in rats; hypothesis-generating with no implications for human therapy.
BACKGROUND: Arterial baroreflex (ABR) is an important factor in preventing of blood pressure fluctuations that determined by baroreflex sensitivity (BRS). Estrogen is an ovarian hormone that has influence on ABR. The mechanism of this effect of estrogen unknown and may be mediated by β-adrenergic receptor of nucleus tractus solitarius (NTS), an important area in regulation of baroreflex. Therefore, in this study changing of BRS by estrogen after blockade β-adrenergic receptor of NTS in ovariectomized rats (Ovx) and Ovx treated with estrogen (Est) was examined. MATERIALS AND METHODS: After ovariectomy, all female rats divided to Ovx and Ovx + Est groups and two series of experiments were performed. In the first experiment, phenylephrine was [intravenously, IV] injected in both the Ovx and Ovx + Est groups, and mean arterial pressure (MAP), heart rate (HR), and BRS were evaluated (n = 8 for each group). In the second experiment, each of Ovx and Ovx + Est groups divided into saline and propranolol (pro) groups, saline and pro stereotaxically were microinjected into NTS, respectively. Further, phenylephrine (IV) was injected in all groups and BRS was evaluated. RESULTS: BRS significantly increased in estrogen-treated groups (Ovx + Est) compared to Ovx groups (P < 0.01). The blockade β-adrenergic receptor of NTS by pro did not significantly changed BRS in both Ovx and Ovx + Est groups. CONCLUSION: We concluded that there aren't any intraction between estrogen and β-adrenergic receptor of NTS in BRS.
Shafei et al. (2014) studied Ovariectomized rats. Estrogen treatment and propranolol microinjection into NTS vs. Ovariectomized rats without estrogen and saline microinjection was evaluated on Baroreflex sensitivity (BRS) (p=<0.01). Estrogen treatment significantly increased baroreflex sensitivity in ovariectomized rats (P<0.01), but blockade of β-adrenergic receptors in the NTS with propranolol did not alter this effect.
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