Key result
In chloralose-anaesthetized cats, vigorous activations of group IV nociceptive receptors were observed during ischaemic work, suggesting they mediate the pain of ischaemic contractions.
Population
Chloralose-anaesthetized cats (131 group III and IV units tested from the triceps surae muscle)
Comparison
Muscular contractions with intact blood supply… vs Contractions with intact blood supply
Design
Preclinical
Authors
Loading...
Supports group IV role in feline ischaemic pain; leaves open human translation and therapeutic targeting.
The pain of ischaemic muscle contractions is likely mediated by nociceptive receptors with non-myelinated afferent fibres (group IV), distinct from those mediating cardiopulmonary adjustments during normal exercise.
Mense et al. (1983) studied Muscle afferent responses to contractions and ischaemia (n=131). Muscular contractions with ischaemia (occlusion of muscle artery) vs. Muscular contractions with intact blood supply was evaluated on Impulse activity of single afferent units from the triceps surae muscle. In chloralose-anaesthetized cats, vigorous activations of group IV nociceptive receptors were observed during ischaemic work, suggesting they mediate the pain of ischaemic contractions.
Synapse has enriched one closely related paper. Consider it for comparative context: