Population
Anesthetized cats (model for cardiac sympathetic afferents)
Comparison
5 min of myocardial ischemia, and topical… vs Mechanically sensitive afferents / baseline…
Design
Preclinical
Authors
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May implicate silent sympathetic afferents in ischemic cardiac nociception; leaves open human translation and clinical relevance.
The study provides evidence that the heart is innervated by silent sympathetic afferents that are profoundly activated by myocardial ischemia, potentially functioning as cardiac nociceptors.
Pan et al. (2002) studied this question.
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