Key result
Intra-arterial injection of algesic agents activated about half of group IV and two thirds of group III muscle afferents, suggesting they mediate chemically induced muscle pain.
Chemically induced muscle pain is likely mediated by group III and IV afferents, not group I or II.
No takes yet. Share an insight, caveat, or question.
Supports group III/IV mediation of chemical muscle pain in cats; extends basic mechanisms while leaving human translation open.
Siegfried Mense (1977) studied Chemically induced muscle pain. Intra-arterial injections of pain-producing substances (bradykinin, 5-hydroxytryptamine, histamine and potassium) was evaluated on Impulse activity of various types of muscle afferents. Intra-arterial injection of algesic agents activated about half of group IV and two thirds of group III muscle afferents, suggesting they mediate chemically induced muscle pain.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: