Key result
Electrical stimulation of low-threshold group III afferent fibers inhibited sympathetic neurones, whereas high-threshold group III and group IV fibers excited them and elicited pressor responses.
Population
Anaesthetized cats with intact neuraxis and spinal cats
Design
Preclinical
Authors
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Animal data on afferent-specific sympathetic control may inform exercise pressor mechanisms; leaves open human translation.
Group III and IV muscle afferents elicit distinct sympathetic and blood pressure responses, suggesting a chemoreceptor function responsible for the pressor reflex during exercise.
Coote et al. (1970) studied this question. Electrical stimulation of afferent fibres was evaluated on Responses of sympathetic neurones and blood pressure reflexes. Electrical stimulation of low-threshold group III afferent fibers inhibited sympathetic neurones, whereas high-threshold group III and group IV fibers excited them and elicited pressor responses.
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