Inhibition of cardiac vagal component of baroreflex by group III and IV afferents

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Population

Decerebrate cats

Comparison

Electrical stimulation of group I, II, III, and… vs Control

Design

Preclinical

Authors

Discussion

Animal findings should not guide clinical baroreflex management; leaves open translation of group III/IV fiber roles to humans.

Population

Decerebrate cats

Intervention

Electrical stimulation (10 Hz) of group I, II, III, and IV fibers of the right peroneal nerve

Comparator

Control (baseline R-R interval prolongation without stimulation)

Outcome

Sensitivity of the baroreceptor reflex (prolongation of R-R interval in response to carotid sinus pressure elevation)surrogate

Inhibition of the cardiac vagal component of the baroreceptor reflex by peroneal nerve stimulation is mediated by group III and IV afferent fibers.

McWilliam et al. (1991) studied this question.

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