Key result
Insulin-mediated cell proliferation in cultured rat vascular smooth muscle cells was significantly reduced by captopril (-38.8%, P<0.05) and losartan (-37.5%, P<0.05).
Why the study?
Does insulin stimulate vascular smooth muscle cell growth via the tissue renin-angiotensin system?
Does insulin stimulate vascular smooth muscle cell growth via the tissue renin-angiotensin system?
p-value: p=<0.05
Insulin promotes vascular smooth muscle cell growth by directly stimulating angiotensinogen expression and translation, an effect mediated through the AT1 receptor and conversion of Ang I to Ang II.
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Suggests angiotensin pathways mediate insulin effects on rat VSMCs; leaves open translation to human vascular disease.
Kamide et al. (1998) studied this question. Insulin with captopril or losartan vs. Insulin alone was evaluated on [3H]thymidine uptake (p=<0.05). Insulin-mediated cell proliferation in cultured rat vascular smooth muscle cells was significantly reduced by captopril (-38.8%, P<0.05) and losartan (-37.5%, P<0.05).
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