Why the study?
Does insulin stimulate angiotensin II production and cell proliferation in cultured rat vascular smooth muscle cells?
Population
Cultured rat vascular smooth muscle cells
Comparison
Insulin incubation for 48 h vs Control (untreated cells)
Design
Preclinical
Follow-up
48 h
Authors
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Does not support practice changes in hyperinsulinemia; leaves open whether angiotensin inhibition mitigates insulin-driven vascular proliferation in vivo.
Does insulin stimulate angiotensin II production and cell proliferation in cultured rat vascular smooth muscle cells?
Insulin stimulates endogenous angiotensin II production and proliferation in vascular smooth muscle cells via a MAPK pathway, providing a potential mechanism linking hyperinsulinemia to atherosclerosis.
Tuck et al. (2004) studied this question.
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