Key result
Transcatheter left ventriculoplasty targets LV geometry to promote reverse remodeling in HFrEF.
Why the study?
Despite advances in HFrEF therapies, a treatment gap remains before advanced heart failure therapies, calling for novel device-based approaches targeting LV geometry and reverse remodelling.
Transcatheter left ventriculoplasty represents an emerging minimally invasive, device-based therapy targeting LV geometry to promote reverse remodeling in HFrEF.
May support device-based LV remodeling in HFrEF; leaves open need for RCTs to confirm safety and efficacy.
Despite significant advances in pharmacological, electrophysiological and valve therapies for heart failure with reduced ejection fraction (HFrEF), the associated morbidity, mortality and healthcare costs remain high. With a constantly growing heart failure population, the existing treatment gap between current and advanced heart failure therapies (e.g., left ventricular [LV] assist devices, heart transplantation) reflects a large unmet need, calling for novel therapeutic approaches. Left ventricular remodelling and dilatation, with or without scar formation, is the hallmark of cardiomyopathy and is associated with poor prognosis. In the era of exciting advances in structural heart interventions, the advent of minimally invasive, device-based therapies directly targeting the LV geometry and promoting physical reverse remodelling has created a new frontier in the battle against heart failure. Interventional heart failure therapy is a rapidly emerging field, encompassing structural heart and minimally invasive hybrid procedures, with two left ventriculoplasty devices currently under investigation in pivotal clinical trials in the US. This review addresses the rationale for left ventriculoplasty, presents the prior surgical and percutaneous attempts in the field, provides an overview of the novel transcatheter left ventriculoplasty devices and their respective trials, and highlights potential challenges associated with establishing such device-based therapies in our armamentarium against heart failure.
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Spilias et al. (2023) conducted a review in Heart failure with reduced ejection fraction (HFrEF). Transcatheter left ventriculoplasty was evaluated. Transcatheter left ventriculoplasty is an emerging device-based therapy targeting left ventricular geometry to promote reverse remodeling in patients with heart failure with reduced ejection fraction.
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