Key result
Synchronous biventricular pacing reversed left ventricular remodeling in heart failure, reducing end-diastolic (245 to 185 mL) and end-systolic volumes (209 to 140 mL) at 3 months (P<0.05).
Why the study?
Does synchronous biventricular pacing reverse left ventricular remodeling and improve symptoms in patients with advanced heart failure and electromechanical conduction delay?
Does synchronous biventricular pacing reverse left ventricular remodeling and improve symptoms in patients with advanced heart failure and electromechanical conduction delay?
Synchronous biventricular pacing for 3 months in patients with advanced heart failure and conduction delay is associated with significant reversal of left ventricular remodeling, improved systolic function, and decreased symptoms.
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May support remodeling reversal with biventricular pacing in advanced HF; leaves open confirmation in randomized trials.
Lau et al. (2000) studied this question. Synchronous biventricular pacing reversed left ventricular remodeling in heart failure, reducing end-diastolic (245 to 185 mL) and end-systolic volumes (209 to 140 mL) at 3 months (P<0.05).
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