Key result
Fluid shear stress induces endothelial shape change and F-actin network remodeling via a mechanism dependent on tyrosine kinase activity, intracellular calcium, and intact microtubules.
Population
Bovine aortic endothelium (BAE) cells
Comparison
Fluid shear stress with and without various… vs Unstressed cells or cells exposed to FSS without…
Design
Preclinical
Authors
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No immediate clinical implications; leaves open translation of shear-dependent endothelial mechanisms to human vascular disease.
Fluid shear stress induces endothelial cell shape change and cytoskeletal remodeling through a mechanism requiring tyrosine kinase activity, intracellular calcium, and intact microtubules.
Malek et al. (1996) studied Endothelial cell shape change and cytoskeletal remodeling. Fluid shear stress (FSS) and pharmacological inhibitors was evaluated on Cell shape change and actin stress fiber induction. Fluid shear stress induces endothelial shape change and F-actin network remodeling via a mechanism dependent on tyrosine kinase activity, intracellular calcium, and intact microtubules.
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