Key result
Clinical depression was significantly associated with higher 5-year mortality compared to non-depressed patients with non-ischaemic heart failure (36% vs 16%; HR 3.0; 95% CI 1.4-6.4; P=0.004).
Why the study?
Does clinical depression increase the risk of mortality and readmission in patients with non-ischaemic heart failure due to dilated cardiomyopathy?
Population
396 consecutive adult patients with non-ischaemic heart failure due to dilated cardiomyopathy, mean age…
Comparison
Clinically recognised depression vs No clinical depression
Design
Cohort
Follow-up
48 months (with 5-year rates reported)
Authors
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Depression was associated with higher mortality in non-ischaemic HF; leaves open whether screening or treatment improves outcomes.
Cohort (n=396)
No
Does clinical depression increase the risk of mortality and readmission in patients with non-ischaemic heart failure due to dilated cardiomyopathy?
Effect estimate: HR 3.0 (95% CI 1.4-6.4)
Absolute Event Rate: 36% vs 16%
p-value: p=0.004
Clinical depression is common and serves as a significant predictor of increased mortality and readmission in patients with non-ischaemic heart failure due to dilated cardiomyopathy.
Faris et al. (2002) conducted a cohort in Non-ischaemic heart failure due to dilated cardiomyopathy (DCM) (n=396). Clinical depression vs. Non-depressed was evaluated on Mortality at 5 years (HR 3.0, 95% CI 1.4-6.4, p=0.004). Clinical depression was significantly associated with higher 5-year mortality compared to non-depressed patients with non-ischaemic heart failure (36% vs 16%; HR 3.0; 95% CI 1.4-6.4; P=0.004).
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