Key result
Tropomyosin isoform switching from larger to smaller isoforms was a transformation-induced change correlated with tumorigenicity in human fibroblasts.
Authors
Loading...
No immediate clinical implications; leaves open tropomyosin switching as a transformation marker for further study.
Leavitt et al. (1986) studied Tumorigenic human fibroblasts. Carcinogen-transformed human fibroblasts (HuT-14) vs. Normal diploid parental fibroblasts and nontumorigenic HuT fibroblasts was evaluated on Tropomyosin isoform synthesis rates and abundance. Tropomyosin isoform switching from larger to smaller isoforms was a transformation-induced change correlated with tumorigenicity in human fibroblasts.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: