Key result
Cloning of a cDNA encoding tropomyosin isoform 3 from tumorigenic human fibroblasts revealed it shares 83% homology with Tm1 and is likely encoded by the alpha-tropomyosin gene via alternative splicing.
Population
Tumorigenic human fibroblast cell line HuT-14, fetal muscle, and cardiac muscle
Design
Preclinical
Authors
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Does not yet alter clinical practice; leaves open the role of alpha-tropomyosin splicing in human cardiovascular disease.
The study identifies that transformation-sensitive tropomyosin isoform 3 is likely generated via alternative RNA splicing from the same gene encoding fast skeletal and smooth muscle alpha-tropomyosins.
Lin et al. (1988) studied this question. Cloning of a cDNA encoding tropomyosin isoform 3 from tumorigenic human fibroblasts revealed it shares 83% homology with Tm1 and is likely encoded by the alpha-tropomyosin gene via alternative splicing.
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