What is the clinical evidence from this study?

Study design: Observational. Population: Multiple organ system failure (n=5248). Intervention: Prognostic estimates for recovery from multiple organ system failure. Primary outcome: Hospital mortality rate.

What does this research mean for the field?

Persistent multiple organ system failure results in consistent and highly predictable mortality outcomes across different populations, with mortality rates of 60% for two failing organs and over 90% for three or more failing organs persisting for more than one day. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the accuracy, reliability, and cross-national consistency of prognostic mortality predictions for intensive care unit patients experiencing multiple organ system failure.

August 1, 1990Medical Decision Making

Prognosis for Recovery from Multiple Organ system failure

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Key result

Prognostic estimates for multiple organ system failure showed consistent outcomes across countries, with hospital mortality rates of 60% for two OSFs and >90% for three or more OSFs persisting >1 day.

Key Points

To evaluate the accuracy, reliability, and cross-national consistency of prognostic mortality predictions for intensive care unit patients experiencing multiple organ system failure.
Applied prognostic recovery estimates derived from a development cohort of 2,843 ICU patients across 13 U.S. hospitals prospectively to 2,405 ICU admissions across 27 French hospitals (total N=5,248).
Analyzed hospital mortality in relation to the specific organ combinations, total number of failing organ systems, and persistence of organ system failure (OSF) beyond one day.
Two persistent organ system failures lasting longer than one day resulted in a hospital mortality rate of 60% in both cohorts.
Three or more persistent organ system failures lasting beyond one day consistently resulted in hospital mortality rates exceeding 90%.
Isolated neurologic failure exhibited the poorest prognosis among individual organ failures, whereas other specific combinations of organ failures produced similar overall survival outcomes.

Study Design

Type

Observational (n=5,248)

Multicenter

Yes

Structured PICO

Population

5,248 intensive care unit (ICU) patients (2,843 from 13 U.S. hospitals and 2,405 from 27 French hospitals) evaluated for recovery from multiple organ system failure (OSF).

Outcome

Hospital mortality ratehard clinical

Prognostic estimates for multiple organ system failure are highly stable across different countries, providing firm reference data for assessing treatment efficacy in the ICU.

Discussion

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Implication

Supports stable multi-country ICU prognosis estimates; extends prior U.S. data but leaves open clinical adoption without RCTs.

Cite This Study

Rauss et al. (1990) conducted an observational in Multiple organ system failure (n=5,248). Prognostic estimates for recovery from multiple organ system failure was evaluated on Hospital mortality rate. Prognostic estimates for multiple organ system failure showed consistent outcomes across countries, with hospital mortality rates of 60% for two OSFs and >90% for three or more OSFs persisting >1 day.

synapsesocial.com/papers/6a0db4bacecdf5fb20ba9190 https://doi.org/10.1177/0272989x9001000302

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Prognosis for Recovery from Multiple Organ system failure

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Prognosis for Recovery from Multiple Organ system failure

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider