What is the clinical evidence from this study?

Study design: Observational. Population: Patients undergoing open heart surgery or diagnostic catheterization (n=24). Intervention: Pulsatile pressure and flow recording and multibranched modeling. Primary outcome: Mechanisms responsible for the contour of pressure and flow waves and vascular impedance.

What question did this study set out to answer?

The study aims to elucidate the mechanisms by which pressure and flow waves behave in human systemic arteries.

March 1, 1980Circulation ResearchOpen Access

Pulsatile flow and pressure in human systemic arteries. Studies in man and in a multibranched model of the human systemic arterial tree.

View Full Paper

Ask AI

Bookmark

Key result

Pulsatile pressure and flow wave contours in human systemic arteries can be explained by an asymmetric T tube model with two reflecting sites, one being 1.5 times further away than the other.

Population

24 human subjects and a multibranched model of the human systemic arterial tree

Authors

MOMichael F. O’RourkeManitoba Health AAAlberto AvolioVascular Medicine

Discussion

Member takes

Implication

Asymmetric T-tube modeling refines arterial waveform analysis; leaves open prospective validation before clinical adoption.

Key Points

The study aims to elucidate the mechanisms by which pressure and flow waves behave in human systemic arteries.
Pulsatile pressure and flow were recorded from the ascending aorta of 24 patients, including 7 undergoing open-heart surgery.
Data were analyzed using a multibranched model of the systemic arterial tree to simulate various conditions.
Input impedance to the systemic circulation was derived from ascending aortic pressure/flow relationships.
Two reflecting sites in the systemic circulation were identified, explaining the relationship between pressure and flow waves.
The concept of the arterial system modeled as an asymmetric T tube was supported by the observations collected.
The findings align with previously published data on pressure and flow waves in human subjects.

Study Design

Type

Observational (n=24)

Structured PICO

Population

24 human subjects (7 undergoing open heart surgery, 17 at diagnostic catheterization) and a multibranched model of the human systemic arterial tree

Intervention

Recording of pulsatile pressure and flow from the ascending aorta and other arteries

Outcome

Mechanisms responsible for the contour of pressure and flow waves and the pattern of vascular impedancesurrogate

The study demonstrates that human systemic arterial pressure and flow waves can be modeled as an asymmetric T tube with two discrete reflecting sites.

Cite This Study

O’Rourke et al. (1980) conducted an observational in Patients undergoing open heart surgery or diagnostic catheterization (n=24). Pulsatile pressure and flow recording and multibranched modeling was evaluated on Mechanisms responsible for the contour of pressure and flow waves and vascular impedance. Pulsatile pressure and flow wave contours in human systemic arteries can be explained by an asymmetric T tube model with two reflecting sites, one being 1.5 times further away than the other.

synapsesocial.com/papers/6a0db70ce51d8d6d0c09cfba https://doi.org/10.1161/01.res.46.3.363

View Full Paper

Ask AI

Bookmark

Pulsatile flow and pressure in human systemic arteries. Studies in man and in a multibranched model of the human systemic arterial tree.

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Pulsatile flow and pressure in human systemic arteries. Studies in man and in a multibranched model of the human systemic arterial tree.

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider