Key result
Right atrial pacing tachycardia induced myocardial lactate abnormalities in 7 of 23 (30.4%) patients with prolapsing mitral leaflet syndrome, compared to 2 (8.7%) during spontaneous heart rate.
Why the study?
Does right atrial pacing induce myocardial metabolic abnormalities in patients with prolapsing mitral leaflet syndrome?
Population
23 patients with prolapsing mitral leaflet syndrome (PML)
Comparison
Right atrial pacing to induce tachycardia vs Control spontaneous heart rate
Design
Case_series
Authors
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May suggest myocardial hypoxia underlies chest pain in prolapsing mitral leaflet syndrome; hypothesis-generating and requires validation in larger studies.
Observational (n=23)
Does right atrial pacing induce myocardial metabolic abnormalities in patients with prolapsing mitral leaflet syndrome?
Absolute Event Rate: 30.4% vs 8.7%
Myocardial lactate abnormalities during pacing-induced tachycardia suggest that chest pain in prolapsing mitral leaflet syndrome may be driven by myocardial hypoxia.
Natarajan et al. (1975) conducted an observational in Prolapsing mitral leaflet syndrome (PML) (n=23). Right atrial pacing tachycardia vs. Control spontaneous heart rate was evaluated on Myocardial lactate abnormalities (lactate production or <10% extraction). Right atrial pacing tachycardia induced myocardial lactate abnormalities in 7 of 23 (30.4%) patients with prolapsing mitral leaflet syndrome, compared to 2 (8.7%) during spontaneous heart rate.
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