Key result
Posterior mitral prolapse links to a ~9 mmHg greater exercise-induced SPAP increase than anterior prolapse.
Why the study?
Does posterior mitral leaflet prolapse compared to anterior mitral leaflet prolapse increase exercise-induced pulmonary hypertension in patients with asymptomatic moderate-to-severe degenerative mitral regurgitation?
Population
35 consecutive patients with asymptomatic, moderate-to-severe, and degenerative mitral regurgitation, mean…
Comparison
Posterior mitral leaflet (PML) prolapse vs Anterior mitral leaflet (AML) prolapse
Design
Cross-sectional
Authors
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PML prolapse linked to greater exercise SPAP rise via dynamic MR; leaves open whether leaflet-specific surveillance alters outcomes in asymptomatic degenerative MR.
Observational (n=35)
Does posterior mitral leaflet prolapse compared to anterior mitral leaflet prolapse increase exercise-induced pulmonary hypertension in patients with asymptomatic moderate-to-severe degenerative mitral regurgitation?
Absolute Event Rate: 35.8% vs 26.7%
p-value: p=0.009
In asymptomatic moderate-to-severe degenerative mitral regurgitation, posterior leaflet prolapse is associated with a greater increase in exercise-induced pulmonary hypertension compared to anterior leaflet prolapse.
Jung et al. (2016) conducted an observational in Asymptomatic, moderate-to-severe, and degenerative mitral regurgitation (n=35). Posterior mitral leaflet (PML) prolapse vs. Anterior mitral leaflet (AML) prolapse was evaluated on Exercise-induced changes in systolic pulmonary artery pressure (ΔSPAP) (p=0.009). Posterior mitral leaflet prolapse was associated with a significantly greater exercise-induced increase in systolic pulmonary artery pressure compared to anterior leaflet prolapse (35.8 vs 26.7 mmHg; P=0.009).
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