Key result
Esmolol and dexmedetomidine similarly decreased haemodynamic indices of myocardial oxygen demand, but neither drug decreased directly measured myocardial oxygen consumption in dogs.
Why the study?
Does dexmedetomidine compared to esmolol reduce myocardial oxygen consumption in an instrumented dog model?
Population
11 mongrel dogs instrumented to measure aortic and left ventricular pressure, aortic and left anterior…
Comparison
Dexmedetomidine vs Esmolol (sequential experimental conditions)
Design
Preclinical
Authors
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Questions hemodynamic surrogates for myocardial oxygen consumption; leaves open effects of either agent on true MVO2.
Does dexmedetomidine compared to esmolol reduce myocardial oxygen consumption in an instrumented dog model?
In a canine model, both esmolol and dexmedetomidine decrease hemodynamic indices of myocardial oxygen demand, but neither decreases directly measured myocardial oxygen consumption.
Willigers et al. (2004) studied Myocardial oxygen consumption (n=11). Dexmedetomidine vs. Esmolol was evaluated on Indices of overall myocardial oxygen demand and directly measured myocardial oxygen consumption. Esmolol and dexmedetomidine similarly decreased haemodynamic indices of myocardial oxygen demand, but neither drug decreased directly measured myocardial oxygen consumption in dogs.
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