Key result
Esmolol preserves hemodynamics and blood flow while decreasing lactate during temporary coronary occlusion in dogs.
Why the study?
Does esmolol infusion decrease hemodynamic and myocardial metabolic impairment during acute coronary artery occlusion in dogs?
Population
23 anesthetized open-chest dogs subjected to two consecutive 15-minute periods of total left anterior…
Comparison
Esmolol infusion during one of the 15-minute… vs No intervention during either occlusion period
Design
Preclinical, Randomly assigned
Follow-up
Two 15-minute occlusion periods separated by 1 hour of…
Authors
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May inform beta-blocker use in acute ischemia; leaves open translation from canine models to patients.
RCT (n=23)
randomly assigned
Does esmolol infusion decrease hemodynamic and myocardial metabolic impairment during acute coronary artery occlusion in dogs?
In a canine model of acute coronary occlusion, esmolol infusion mitigated hemodynamic deterioration, preserved regional myocardial blood flow, and reduced myocardial lactate production.
Sidi et al. (1988) conducted an RCT in Acute Coronary Artery Occlusion (n=23). Esmolol vs. No intervention was evaluated on Hemodynamic and myocardial metabolic impairment. Esmolol infusion during temporary coronary artery occlusion in dogs preserved hemodynamic variables and endocardial-to-epicardial blood flow, and decreased lactate production.
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