Key result
In a porcine model of acute myocardial infarction, esmolol infusion significantly reduced left ventricular ejection fraction from 34.08% to 30.75% and worsened torsional parameters.
Why the study?
Early intravenous use of beta-blockers within the first hours of STEMI is less firmly established.
Does esmolol infusion affect LV haemodynamic, rotational and strain parameters in intact and infarcted myocardium in a pig model?
Does esmolol infusion affect LV haemodynamic, rotational and strain parameters in intact and infarcted myocardium in a pig model?
Absolute Event Rate: 30.75% vs 34.08%
p-value: p=0.014
Esmolol infusion acutely deteriorates LV haemodynamics and strain in a pig model of acute MI, suggesting early IV beta-blockade in STEMI may be risky before stabilization.
No takes yet. Share an insight, caveat, or question.
Esmolol impairs LV function early post-MI; challenges routine acute beta-blockade and supports stabilization first.
Toumanidis et al. (2020) studied Acute myocardial infarction (experimental) (n=20). Esmolol vs. Baseline (no esmolol) in the same subjects was evaluated on Left ventricular ejection fraction (%) post-MI (p=0.014). In a porcine model of acute myocardial infarction, esmolol infusion significantly reduced left ventricular ejection fraction from 34.08% to 30.75% and worsened torsional parameters.
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