Key result
Exercise-induced R wave amplitude changes showed no clear correlation with the angiographic severity of coronary artery disease when evaluated at similar heart rate steps, suggesting differences at peak exercise are artifactual due to varying exercise tolerance.
Why the study?
Do exercise-induced R wave amplitude changes correlate with the angiographic severity of coronary artery disease?
Observational (n=195)
No
Do exercise-induced R wave amplitude changes correlate with the angiographic severity of coronary artery disease?
Exercise-induced R wave amplitude changes do not reliably correlate with the angiographic severity of coronary artery disease during effort.
R-wave changes lack correlation with CAD severity at matched heart rates; hypothesis-generating that peak differences reflect tolerance artifacts rather than ischemia.
The correlation between R wave voltage variations (delta R) and the angiographic severity of coronary artery disease (CAD) at progressively increasing heart rate (HR) steps was evaluated in 51 patients (pts) without CAD (OV), in 42 pts with single (SVD), in 43 with double (DVD) and in 59 pts with triple vessel disease (TVD). At the end of stress the sensitivity of delta R was higher in DVD and TVD pts than in SVD pts. There was no clear correlation between exercise-induced R wave changes and the angiographic severity of CAD, since the qualitative and quantitative delta R evaluation during effort showed similar changes in delta R for a wide range of HR's in the entire study population. Since different degrees of exercise tolerance were found in pts with SVD, DVD and TVD, we hypothesize that the correlation between delta R and the severity of CAD at the end of stress testing may be artifactual.
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Caprio et al. (1984) conducted an observational in Coronary Artery Disease (n=195). Exercise stress testing (evaluation of R wave amplitude changes) vs. Patients without coronary artery disease was evaluated on Correlation between exercise-induced R wave changes and angiographic severity of CAD. Exercise-induced R wave amplitude changes showed no clear correlation with the angiographic severity of coronary artery disease when evaluated at similar heart rate steps, suggesting differences at peak exercise are artifactual due to varying exercise tolerance.
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