Key result
TAVI appears to offer greater benefit than surgery for women with degenerative aortic stenosis.
Why the study?
The impact of sex on baseline characteristics and presentation of degenerative aortic stenosis is poorly understood despite being widely demonstrated, and women appear to derive greater benefit from TAVI compared with surgery.
This review highlights sex-specific differences in degenerative aortic stenosis and suggests women may derive greater benefit from TAVI compared to surgical treatment.
Answers are grounded in this paper and cite their sources.
Should not yet alter aortic stenosis treatment choices; leaves open sex-specific TAVI benefit pending randomized confirmation.
The impact of sex on baseline characteristics and morphological and clinical presentation of degenerative aortic stenosis has been widely demonstrated but poorly understood. Moreover, differently from valve surgery, where patients were predominantly male, both sexes have been well represented in percutaneous treatment of aortic stenosis (AS), and women appeared to derive greater benefit with transfemoral aortic valve implantation (TAVI) compared to surgical treatment. This review focuses on sex-specific differences in epidemiology, pathophysiology, diagnostic issues, treatment options, and clinical outcomes of degenerative AS. Moreover, we evaluate how sex-based TAVI management, from device selection to procedural tricks, may affect outcomes.
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Masiero et al. (2022) conducted a review in Degenerative aortic stenosis. Transfemoral aortic valve implantation (TAVI) vs. Surgical treatment was evaluated. Women appear to derive greater benefit with transfemoral aortic valve implantation (TAVI) compared to surgical treatment for degenerative aortic stenosis.
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