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February 12, 2026Interdisciplinary CardioVascular and Thoracic SurgeryOpen Access

Sex-related differences after transcatheter aortic valve implantation: A retrospective propensity-matched cohort

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Key result

Women show better overall survival post-TAVI than men despite experiencing more strokes.

  • p<0.01

Why the study?

Sex differences in outcomes after TAVI remain incompletely understood, and contemporary evidence beyond earlier device generations is limited.

Does female sex compared to male sex affect clinical outcomes and mortality after transcatheter aortic valve implantation?

Population

2,718 patients with severe aortic stenosis undergoing TAVI

Comparison

Women vs men

Design

Retrospective propensity-matched cohort study

Follow-up

30 days

Authors

MEMaroua EidUniversité d'AngersFPFrédéric PinaudCardiac SurgerySVSimon Dang VanCardiac Surgery

Discussion

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Overview

Sex differences in contemporary TAVI outcomes persist; observational data leave open whether sex-specific strategies are warranted.

Key Points

  • This research investigates sex differences in outcomes following transcatheter aortic valve implantation (TAVI).
  • Retrospective analysis of patients with severe aortic stenosis undergoing TAVI from 2012 to 2023.
  • Data on clinical and procedural characteristics were collected from a dedicated database.
  • Propensity-score matching was used to account for baseline differences between sexes.
  • A total of 2,718 patients underwent TAVI, with nearly half being women.
  • 30-day mortality did not differ between sexes, but all-cause mortality was higher in men.
  • Women had a higher incidence of postoperative stroke, while men had more acute renal failure and pacemaker implants.
  • Survival probability was greater for women in the overall population and low- to intermediate-risk groups.

Structured PICO

Does female sex compared to male sex affect clinical outcomes and mortality after transcatheter aortic valve implantation?

P
Population
2,718 patients with severe aortic stenosis who underwent transcatheter aortic valve implantation (TAVI) between January 2012 and December 2023
I
Intervention
Transcatheter aortic valve implantation (TAVI) in women
C
Comparator
Transcatheter aortic valve implantation (TAVI) in men (propensity-score matched 1:1)
O
Outcome
30-day mortalityhard clinical

In a contemporary TAVI cohort, significant sex-specific differences persist, with women experiencing more strokes but better overall survival, while men face higher all-cause mortality and conduction-related complications.

Cite This Study

Eid et al. (2026) studied this question. After propensity matching, men had significantly higher all-cause mortality post-TAVI (p<0.01), while women had more strokes but better overall survival.

synapsesocial.com/papers/698d6e925be6419ac0d546e7https://doi.org/10.1093/icvts/ivag034
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