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August 25, 2014Journal of Interventional Cardiology

Influence of Sex on Outcome Following Transcatheter Aortic Valve Implantation (TAVI): Systematic Review and Meta‐Analysis

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Key result

Female sex was associated with a significantly lower 30-day mortality rate compared to male sex following transcatheter aortic valve implantation (OR 0.78; 95% CI 0.64-0.96).

Why the study?

Does female sex improve survival outcomes in patients undergoing TAVI for aortic stenosis?

Population

7,973 patients with aortic stenosis treated with all forms of TAVI, pooled from 14 observational studies

Comparison

Female sex (TAVI in women) vs Male sex (TAVI in men)

Design

Meta-analysis

Follow-up

30 days and during follow-up

Authors

VSVerena StanglGBGerd BaldenhoferMLMichael Laule

Discussion

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Member takes

Overview

May inform sex-specific risk counseling in TAVI; extends meta-analytic evidence on short-term survival differences.

Study Design

Type

Meta-Analysis (n=7,973)

Structured PICO

Does female sex improve survival outcomes in patients undergoing TAVI for aortic stenosis?

P
Population
7,973 patients with aortic stenosis treated with TAVI across 14 observational studies to evaluate sex differences in outcomes.
E
Exposure
Female sex (TAVI in women)
C
Comparator
Male sex (TAVI in men)
O
Outcome
30-day all-cause death and mortality during follow-uphard clinical

Main Result

Odds Ratio: 0.78 (95% CI 0.64–0.96)

Women undergoing TAVI for aortic stenosis have a significant survival advantage over men at 30 days and during follow-up, despite a higher risk of major vascular complications.

Cite This Study

Stangl et al. (2014) conducted a meta-analysis in Aortic stenosis (n=7,973). Female sex vs. Male sex was evaluated on 30-day mortality (OR 0.78, 95% CI 0.64-0.96). Female sex was associated with a significantly lower 30-day mortality rate compared to male sex following transcatheter aortic valve implantation (OR 0.78; 95% CI 0.64-0.96).

synapsesocial.com/papers/6a99a37bd4ecc439fa15813chttps://doi.org/10.1111/joic.12150
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sex-Related Differences in Outcomes After Transcatheter or Surgical Aortic Valve Replacement in Patients With Severe Aortic Stenosis2014 · 199 citations
  2. 2Sex differences in postprocedural aortic regurgitation and mid‐term mortality after transcatheter aortic valve implantation2014 · 34 citations
  3. 3Transcatheter Aortic Valve Implantation for the Treatment of Severe Symptomatic Aortic Stenosis in Patients at Very High or Prohibitive Surgical Risk2010 · 981 citations
  4. 4Incidence and Predictors of Early and Late Mortality After Transcatheter Aortic Valve Implantation in 663 Patients With Severe Aortic Stenosis2011 · 1,126 citations