Why the study?
Sex-based morphological, physiological, and baseline characteristic differences may impact outcomes between sexes after TAVR.
Do outcomes after transcatheter aortic valve replacement (TAVR) differ between female and male patients?
Population
657,850 patients (351,927 males and 305,923 females) undergoing TAVR across 58 studies
Comparison
Female vs male patients
Design
Meta-analysis and meta-regression
Follow-up
Up to 1 year
Key result
Female patients undergoing TAVR had higher in-hospital mortality (RR 1.16; 95% CI 1.02-1.32; p=0.02) but lower 1-year mortality (RR 0.87; 95% CI 0.82-0.93; p<0.01) compared to males.
Authors
Loading...
Females may warrant heightened periprocedural vigilance during TAVR; leaves open whether sex-specific strategies improve net outcomes.
Meta-Analysis (n=657,850)
Do outcomes after transcatheter aortic valve replacement (TAVR) differ between female and male patients?
Effect estimate: RR 1.16 (95% CI 1.02-1.32)
p-value: p=0.02
In patients undergoing TAVR, females face higher short-term risks including in-hospital mortality, stroke, and bleeding, but have lower 1-year all-cause mortality compared to males.
Benhammou et al. (2025) conducted a meta-analysis in symptomatic aortic stenosis (AS) (n=657,850). Female sex vs. Male sex was evaluated on in-hospital mortality (RR 1.16, 95% CI 1.02-1.32, p=0.02). Female patients undergoing TAVR had higher in-hospital mortality (RR 1.16; 95% CI 1.02-1.32; p=0.02) but lower 1-year mortality (RR 0.87; 95% CI 0.82-0.93; p<0.01) compared to males.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: