Why the study?
Females with severe aortic stenosis present with distinct anatomical and clinical characteristics compared to males, which may influence outcomes after TAVR.
Does female sex influence short- and long-term clinical outcomes in patients undergoing TAVR compared to male sex?
Population
Patients with severe aortic stenosis undergoing TAVR
Comparison
Females vs males
Design
Meta-analysis of reconstructed individual patient survival data from randomized and observational studies
Follow-up
Extending to 10 years
Key result
Females undergoing TAVR exhibited a sustained long-term survival advantage compared with males over up to 10 years of follow-up (P<0.001).
Authors
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May warrant sex-specific periprocedural strategies in TAVR; extends evidence to decade-long survival data.
Meta-Analysis
Does female sex influence short- and long-term clinical outcomes in patients undergoing TAVR compared to male sex?
p-value: p=< 0.001
Females undergoing TAVR face higher early periprocedural risks but achieve better long-term survival than males, highlighting the need for sex-centered periprocedural management.
Abdelaziz et al. (2026) conducted a meta-analysis in severe aortic stenosis. Female sex vs. Male sex was evaluated on long-term survival (p=< 0.001). Females undergoing TAVR exhibited a sustained long-term survival advantage compared with males over up to 10 years of follow-up (P<0.001).
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