Key result
Male sex is linked to ~24% higher 5-year all-cause mortality after TAVR compared to women.
Why the study?
The impact of sex-related differences on outcomes following transcatheter aortic valve replacement remains inconclusive.
Does male sex compared to female sex worsen survival and safety outcomes in patients with aortic stenosis undergoing TAVR?
Population
69 355 women and 65 580 men with aortic stenosis undergoing TAVR across 48 studies
Comparison
Men vs women
Design
Meta-analysis of reconstructed individual patient time-to-event data
Authors
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Men warrant intensified long-term surveillance after TAVR; extends prior data by confirming sustained 5-year mortality excess despite fewer procedural complications.
Meta-Analysis (n=134,935)
Does male sex compared to female sex worsen survival and safety outcomes in patients with aortic stenosis undergoing TAVR?
Hazard Ratio: 1.24 (95% CI 1.2–1.28)
p-value: p=< 0.001
Following TAVR, men have significantly worse 5-year overall and 4-year cardiovascular survival compared to women, despite experiencing fewer periprocedural vascular and bleeding complications.
Tavakoli et al. (2025) conducted a meta-analysis in Aortic stenosis undergoing TAVR (n=134,935). Male sex vs. Female sex was evaluated on All-cause mortality at 5 years (HR 1.24, 95% CI 1.20-1.28, p=< 0.001). Men undergoing TAVR had a significantly higher risk of all-cause mortality at 5 years compared with women (HR 1.24; 95% CI 1.20-1.28; P < 0.001).
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