Key result
Female sex is linked to better survival after TAVR versus men despite more early complications.
Why the study?
Outcomes after transcatheter aortic valve replacement based on an individual's sex remain to be fully elucidated.
Do outcomes after transcatheter aortic valve replacement differ between women and men?
Population
Patients ineligible for or at high risk for surgery undergoing TAVR from 23 publications
Comparison
Women versus men after TAVR
Design
Literature review
Follow-up
30 days
Authors
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May support sex-specific TAVR risk discussions; leaves open mechanisms and need for prospective validation.
Do outcomes after transcatheter aortic valve replacement differ between women and men?
Effect estimate: HR 0.27 to 0.91 (95% CI 0.09-0.84 to 0.75-1.10)
Following TAVR, women appear to have better survival than men but face higher risks of 30-day vascular and bleeding complications, which may be partly explained by differences in baseline comorbidities.
Azarbaijani et al. (2017) conducted a review in Aortic valve replacement. Female sex vs. Male sex was evaluated on Survival (HR 0.27 to 0.91, 95% CI 0.09-0.84 to 0.75-1.10). Female sex was associated with better survival after TAVR compared to men (HR range 0.27 to 0.91), despite higher 30-day rates of vascular complications and bleeding.
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