Key result
Female sex is linked to better mid-term TAVI survival despite higher vascular complications.
Why the study?
Women undergoing TAVI have different baseline characteristics and outcomes compared to men, motivating a review of gender differences and sex-specific factors affecting results.
Does female sex impact clinical outcomes and procedural characteristics in patients undergoing TAVI?
Does female sex impact clinical outcomes and procedural characteristics in patients undergoing TAVI?
Despite higher peri-procedural complication rates, women undergoing TAVI have favorable clinical outcomes compared to men, likely driven by fewer baseline comorbidities and preserved left ventricular ejection fraction.
Answers are grounded in this paper and cite their sources.
Women may derive mid-term TAVI survival benefit despite vascular complications; hypothesis-generating and requires prospective validation before practice change.
Transcatheter aortic valve implantation (TAVI) has emerged as an alternative treatment for severe symptomatic aortic stenosis in patients who are not suitable for surgery or are at high surgical risk. Approximately 50% of patients undergoing TAVI are female and this is reflected by a higher inclusion rate of women in TAVI trials. However, women undergoing TAVI have different baseline clinical characteristics in comparison to men, with fewer comorbidities and a more preserved left ventricular ejection fraction. This translates into favourable outcomes after TAVI, despite a higher rate of peri-procedural complications. This article discusses gender differences in terms of presentation, procedural characteristics and post-procedural results in patients with aortic stenosis undergoing TAVI, with particular focus on possible sex-specific factors affecting outcome.
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Laricchia et al. (2019) conducted a review in Severe symptomatic aortic stenosis. Female sex vs. Male sex was evaluated. Female patients undergoing transcatheter aortic valve implantation demonstrate a mid-term survival benefit compared to men, despite experiencing a higher incidence of periprocedural vascular complications.
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