Key result
Female patients undergoing transcatheter aortic valve replacement exhibit distinct morbidity and mortality outcomes compared to males, with most data indicating improved long-term mortality in females.
Why the study?
Does patient sex influence short- and long-term morbidity and mortality in patients undergoing TAVR?
Does patient sex influence short- and long-term morbidity and mortality in patients undergoing TAVR?
Answers are grounded in this paper and cite their sources.
Female patients undergoing TAVR for severe aortic stenosis generally exhibit improved long-term mortality compared to males, though this survival advantage may be attenuated in intermediate-risk populations.
Since the publication of the pivotal PARTNER study, the transcatheter aortic valve replacement (TAVR) procedure has been established as a noninferior alternative to the traditional aortic valve replacement surgery in severe aortic stenosis (AS) patients with high-surgical risk. Approximately 50% of patients undergoing TAVR are females, and cumulative findings from various worldwide cohorts have shown sex-related differences in short- and long-term morbidity and mortality. Notably, most data indicate improved long-term mortality in female patients. These differences are partly the results of distinct anatomical and physiologic characteristics in female patients, compared with male patients. Nevertheless, recent data from intermediate-surgical risk cohorts have demonstrated that sex-related mortality differences are less apparent. Here, we review the latest literature on the influence of patient's sex on TAVR morbidity and mortality and discuss possible explanations for the outcomes presented.
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Zadok et al. (2017) conducted a review in Severe aortic stenosis (AS). Female sex in patients undergoing TAVR vs. Male sex was evaluated on Short- and long-term morbidity and mortality. Female patients undergoing transcatheter aortic valve replacement exhibit distinct morbidity and mortality outcomes compared to males, with most data indicating improved long-term mortality in females.
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