Key result
Male gender is linked to lower 30-day TAVI mortality but similar long-term survival versus women.
Why the study?
Are there gender-related differences in short- and long-term outcomes among patients with inoperable or high-risk symptomatic aortic stenosis undergoing TAVI?
Population
819 patients with inoperable or high-risk symptomatic aortic stenosis undergoing TAVI, 49% men, from a…
Comparison
Transcatheter aortic valve implantation in men vs Transcatheter aortic valve implantation in women
Design
Cohort
Follow-up
mean 497 ± 478 days
Authors
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Short-term mortality difference by sex after TAVI needs validation; leaves open whether gender influences outcomes independently of confounders.
Cohort (n=819)
Yes
Are there gender-related differences in short- and long-term outcomes among patients with inoperable or high-risk symptomatic aortic stenosis undergoing TAVI?
Hazard Ratio: 0.92 (95% CI 0.71–1.19)
Absolute Event Rate: 25.9% vs 29.7%
p-value: p=0.52
Women undergoing TAVI have higher 30-day mortality driven by bleeding and vascular complications, but long-term mortality is similar to men.
Katz et al. (2016) conducted a cohort in Inoperable or high-risk symptomatic aortic stenosis (n=819). Male gender vs. Female gender was evaluated on Cumulative all-cause mortality (HR 0.92, 95% CI 0.71-1.19, p=0.52). Male gender was associated with lower 30-day mortality after TAVI compared to women, but long-term cumulative all-cause mortality was similar (25.9% vs 29.7%; HR 0.92; 95% CI 0.71-1.19; P=0.52).
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