Key result
This review discusses the association between antimuscarinic drug prescribing and adverse outcomes, proposing novel ways to improve trial design and identify patients at highest risk of side effects.
Why the study?
Does prescribing antimuscarinic drugs cause adverse effects in older people?
Does prescribing antimuscarinic drugs cause adverse effects in older people?
This paper discusses the association between antimuscarinic drugs and adverse outcomes in older people, proposing ways to improve trial design and data collection to identify high-risk patients.
Answers are grounded in this paper and cite their sources.
Supports cautious antimuscarinic prescribing in older adults; leaves open refined trial designs to identify highest-risk patients.
Many commonly prescribed medications have antimuscarinic side effects. These can be severe and disabling, but it is not always possible to predict which patients will suffer these effects. The development of practical tools that predict the likelihood of adverse drug reactions would aid rational prescribing, thereby improving patient safety and outcomes. Avoiding predictable adverse drug reactions would also make significant cost savings. This paper discusses the current knowledge on the association between the prescribing of antimuscarinic drugs and adverse outcomes, and proposes novel ways to improve trial design, and data collection and interpretation in order to better identify those patients at the highest risk of antimuscarinic side effects.
No takes yet. Share an insight, caveat, or question.
Bostock et al. (2010) conducted a review in Antimuscarinic adverse effects. Antimuscarinic drugs was evaluated. This review discusses the association between antimuscarinic drug prescribing and adverse outcomes, proposing novel ways to improve trial design and identify patients at highest risk of side effects.
Synapse has enriched 10 related papers. Consider them for comparative context: