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March 1, 1976Journal of Gerontology

The Effect of Age on Creatinine Clearance in Men: A Cross-sectional and Longitudinal Study

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Key result

Advancing age in normal men is associated with a progressive linear decline in creatinine clearance from 140 ml/min/1.73m2 at age 30 to 97 at age 80, representing true renal aging.

Population

884 male subjects of the Baltimore Longitudinal Study, including 548 normal subjects without specific…

Design

Cohort

Follow-up

3 or more serial clearances at 12- to 18-month intervals

Authors

JRJohn W. RoweColumbia UniversityRAR. AndresNational Institute on AgingJTJ. D. TobinDr. Somervell Memorial CSI Medical College and Hospital

Discussion

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Implication

Supports physiologic renal aging in men; leaves open modifiability and applicability to women or interventions.

Study Design

Type

Observational (n=884)

Structured PICO

P
Population
884 male subjects of the Baltimore Longitudinal Study, including 548 normal subjects without specific diseases or medications altering glomerular filtration rate.
O
Outcome
Creatinine clearancesurrogate

Creatinine clearance progressively declines with age in normal men, representing true renal aging rather than secondary disease effects.

Cite This Study

Rowe et al. (1976) conducted an observational in Normal aging (n=884). Advancing age was evaluated on 24-hour creatinine clearance. Advancing age in normal men is associated with a progressive linear decline in creatinine clearance from 140 ml/min/1.73m2 at age 30 to 97 at age 80, representing true renal aging.

synapsesocial.com/papers/6a0e1aaa370e1ecbafd08ba9https://doi.org/10.1093/geronj/31.2.155
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Longitudinal Studies on the Rate of Decline in Renal Function with Age1985 · 1,591 citations
  2. 2The Age‐Associated Decline in Glomerular Filtration in Healthy Normotensive Volunteers1990 · 50 citations
  3. 3A Longitudinal Study of Urinary Creatinine and Creatinine Clearance in Normal Subjects: Race, Sex, and Age Differences1988 · 206 citations
  4. 4RAPID EVALUATION OF CREATININE CLEARANCE1974 · 270 citations
  5. 5Kidney function changes with aging in adults: comparison between cross‐sectional and longitudinal data analyses in renal function assessment2015 · 14 citations