Key result
Patients with both hypertension and diabetes had significantly greater mean heart weight and microscopic fibrosis compared to those with either condition alone, correlating with collagen levels (p<0.01).
Why the study?
Does the combination of hypertension and diabetes increase heart weight and myocardial fibrosis compared to either condition alone?
Observational (n=67)
Does the combination of hypertension and diabetes increase heart weight and myocardial fibrosis compared to either condition alone?
p-value: p=<0.01
The synergistic effect of hypertension and diabetes leads to more severe myocardial fibrosis and increased heart weight, which may underlie the pathogenesis of hypertensive-diabetic cardiomyopathy and heart failure.
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Suggests synergistic remodeling in comorbid hypertension and diabetes; hypothesis-generating and leaves open need for prospective validation.
Hoeven et al. (1990) conducted an observational in Hypertensive and diabetic heart disease (n=67). Hypertension and/or diabetes mellitus vs. Comparison among hypertensive, diabetic, and hypertensive-diabetic groups was evaluated on Heart weight and amount of fibrosis (p=<0.01). Patients with both hypertension and diabetes had significantly greater mean heart weight and microscopic fibrosis compared to those with either condition alone, correlating with collagen levels (p<0.01).
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