Key result
Published RCTs of antibacterial prophylaxis in colorectal surgery demonstrated inadequate quality, with 56 papers scoring a mean of 61.6 out of 100 and only 23% scoring above 70.
Population
56 published papers between 1979 and 1986 testing regimens of antibacterial bowel preparation before…
Design
Review
Authors
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Historical RCTs of colorectal antibacterial prophylaxis warrant caution due to poor quality; leaves open need for contemporary high-quality trials.
Systematic Review (n=56)
Published RCTs of antibacterial prophylaxis in colorectal surgery between 1979 and 1986 suffered from significant methodological and reporting inadequacies, with no improvement over the 7-year period.
Evans et al. (1987) conducted a systematic review in Antibacterial prophylaxis in colorectal surgery (n=56). Antibacterial bowel preparation was evaluated on Numerical score assessing publications of random control clinical trials (maximum 100). Published RCTs of antibacterial prophylaxis in colorectal surgery demonstrated inadequate quality, with 56 papers scoring a mean of 61.6 out of 100 and only 23% scoring above 70.
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