Key result
A review of 45 clinical trials on antibiotic prophylaxis for abdominal operations found unsatisfactory randomization in 4, questionable ethics in 22, incorrect statistics in 31, and inadequate presentation in 40.
Population
45 articles from the English literature recorded in Index Medicus in 1980 and 1981 on methods of antibiotic…
Design
Systematic_review
Authors
Loading...
Prevalent methodological flaws in antibiotic prophylaxis trials warrant caution when applying their findings; challenges the reliability of much prior evidence.
A review of 45 clinical trials on antibiotic prophylaxis for abdominal operations revealed widespread methodological flaws, including incorrect statistical methods in 31 trials and inadequate presentation in 40.
Mary Evans (1984) conducted a review in Wound infection after abdominal operations (n=45). Antibiotic prophylaxis vs. Control was evaluated on Defects in design, analysis, and presentation. A review of 45 clinical trials on antibiotic prophylaxis for abdominal operations found unsatisfactory randomization in 4, questionable ethics in 22, incorrect statistics in 31, and inadequate presentation in 40.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: