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This review describes the difficulties encountered at a single institution participating in a multicenter drug study and the challenges of developing high-quality randomized controlled trials.
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Highlights logistical barriers to high-quality surgical RCTs; leaves open scalable solutions for multicenter trial success.
Randomized controlled trials are the gold standard for the evaluation of new therapies and surgical procedures and as such require strict attention to study design and statistical analysis. There are, however, multiple challenges in conducting a well-designed clinical trial. This article describes the difficulties encountered at a single institution participating in a multicenter drug study and reviews the challenges involved in developing a high-quality randomized controlled study.
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Lillian S. Kao (2003) reported a review. This review describes the difficulties encountered at a single institution participating in a multicenter drug study and the challenges of developing high-quality randomized controlled trials.
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