Key result
Tenascin deposition was intensely observed along the margin of replacement fibrotic lesions in all 8 patients with dilated cardiomyopathy, suggesting fibrosis is a continuous process.
Population
8 patients with dilated cardiomyopathy
Comparison
Endomyocardial biopsy with… vs Control specimens
Design
Cross-sectional
Authors
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Supports continuous fibrosis in DCM; hypothesis-generating for tenascin-targeted therapies pending prospective validation.
Observational (n=8)
Tenascin expression is localized to the margins of fibrotic lesions in dilated cardiomyopathy, suggesting that fibrosis is an ongoing, continuous process in these patients.
Tamura et al. (1996) conducted an observational in Dilated cardiomyopathy (n=8). Tenascin expression analysis vs. Control specimens was evaluated on Localisation of tenascin in biopsy specimens. Tenascin deposition was intensely observed along the margin of replacement fibrotic lesions in all 8 patients with dilated cardiomyopathy, suggesting fibrosis is a continuous process.
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