Key result
Reduced exercise biventricular cardiac power output reserve linked to ~177% higher HF hospitalization or death risk.
Why the study?
Cardiac and extracardiac abnormalities play important roles in HFpEF, and biventricular cardiac power output may help identify patients with more severe cardiac impairments to better individualize treatment.
Does low biventricular cardiac power output reserve predict heart failure hospitalization or death in patients with HFpEF?
Population
398 patients with HFpEF
Comparison
Low BCPO reserve (< median of 1.57 W) vs preserved BCPO reserve
Design
Cohort study
Follow-up
2.9 (interquartile range 0.9-4.5) years
Authors
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May aid risk stratification in HFpEF; leaves open whether targeting biventricular reserve improves outcomes.
Cohort (n=398)
Does low biventricular cardiac power output reserve predict heart failure hospitalization or death in patients with HFpEF?
Effect estimate: HR 2.77 (95% CI 1.73-4.42)
p-value: p=< 0.0001
In patients with HFpEF, an inability to enhance biventricular cardiac power output during exercise is a strong predictor of adverse clinical outcomes, including heart failure hospitalization and death.
Alogna et al. (2023) conducted a cohort in Heart failure with preserved ejection fraction (HFpEF) (n=398). Low biventricular cardiac power output (BCPO) reserve vs. Preserved BCPO reserve was evaluated on Composite of heart failure hospitalization or death (HR 2.77, 95% CI 1.73-4.42, p=< 0.0001). Reduced biventricular cardiac power output reserve during exercise was associated with an increased risk of heart failure hospitalization or death (HR 2.77; 95% CI 1.73-4.42; p < 0.0001).
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