Key result
HELT-E2S2 score ≥4 linked to ~232% greater mortality risk vs score 0-1 in ADHF.
Why the study?
The HELT-E2S2 score is a novel risk tool for ischemic stroke in AF, but its prognostic utility for cardiovascular outcomes in HF patients beyond its original scope was unknown.
Does the HELT-E2S2 score predict cardiovascular outcomes in patients with acute decompensated heart failure?
Cohort (n=997)
Yes
Does the HELT-E2S2 score predict cardiovascular outcomes in patients with acute decompensated heart failure?
The study explores the prognostic utility of the HELT-E2S2 score, originally designed for stroke risk assessment in atrial fibrillation, for predicting cardiovascular outcomes in acute decompensated heart failure.
Should not yet change practice in acute decompensated heart failure; extends HELT-E2S2 associations to mortality in this population.
Background The HELT-E2S2 score is a novel risk assessment tool for ischemic stroke in patients with atrial fibrillation (AF). We explored the prognostic impact of the HELT-E2S2 score on cardiovascular outcomes in patients with heart failure (HF), beyond its original scope.
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Tanaka et al. (2025) conducted a cohort in Acute Decompensated Heart Failure (n=997). HELT-E2S2 score ≥4 vs. HELT-E2S2 score 0 or 1 was evaluated on All-cause death (HR 3.32, 95% CI 2.34-4.94, p=<0.001). A HELT-E2S2 score of ≥4 was associated with a significantly increased risk of all-cause death compared to a score of 0 or 1 (HR 3.32) in patients with acute decompensated heart failure.
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